Here in Connecticut, fentanyl and xylazine have long been found in the drug supply. A small amount of fentanyl is all that’s needed to cause a death; and the animal tranquilizer xylazine can be lethal when used by humans. Recently, new drugs have been observed in overdose deaths, which is why it’s important to know what drugs you’re taking and to get your drugs tested.
The newer drugs include designer benzodiazepines, carfentanil, kratom, medetomidine, nitazenes, and orphines (cychlorphine). Read below for more information about each of these drugs.
Designer benzodiazepines refer to a class of illegally made benzodiazepine medications that slow down activity in the brain and nervous system. They are much more potent than prescribed benzodiazepines.
Carfentanil is a synthetic opioid. It is approximately 100 times more potent than fentanyl (see above) and 10,000 times more potent than morphine; it was originally developed as a tranquilizer for large animals.
Kratom is an herbal extract that users can chew in leaf-form, swallow or brew dry, or drink as a liquid. It is used as a stimulant at low doses, and as a sedative at higher doses. Although kratom is banned in Connecticut, it is still widely available in neighboring states at gas station convenience stores and in health stores, marketed as a mood booster and remedy for opioid withdrawal. It is not FDA approved.
Medetomidine belongs to the same family of drugs as xylazine (see above). It is used as a veterinary sedative and is synthetically manufactured. The effects of medetomidine can include sedation, low heart rate, low blood pressure, and hallucinations. Medetomidine is not an opioid.
Nitazenes are very powerful synthetic opioids. Nitazenes are not approved for any medical use.
Orphines (Cychlorphine) are potent synthetic opioids chemically similar to fentanyl and nitazenes; cychlorphine may be 50 to 200 times stronger than heroin, and 10 times stronger than fentanyl.
According to the CDC, polysubstance overdose deaths have increased. Polysubstance drug use means using more than one drug either intentionally or unintentionally.
Unintentional polysubstance use occurs when a person takes drugs that have been mixed or cut with other substances. Street drugs are often a mix of multiple substances. Because of this, it is always recommended to use naloxone when an overdose is suspected. If a polysubstance overdose involves an opioid, naloxone can still revive the person. It is always worth trying to save someone when an overdose is suspected, even if you do not know what substances are involved. Administer naloxone and call 911 for additional support.